Loss of Feedback Control of Hydroxymethylglutaryl Coenzyme A Reductase in Hepatomas
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چکیده
منابع مشابه
Loss of feedback control of hydroxymethylglutaryl coenzyme A reductase in hepatomas.
THE FEEDBACK RESPONSE OF MEVALONATE: NADP oxidoreductase (acylating CoA; EC 1.1.1.34) in two varieties of hepatoma has been examined. In marked contrast to the feedback inhibition of this enzyme that is regularly observed in normal liver, the feedback control is completely lost in minimal-deviation hepatomas 9121 and 3924A. This finding provides the first specific biochemical localization of th...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1971
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.68.2.315